Supplementary Material for: Determining Stroke Onset Time Using Quantitative MRI: High Accuracy, Sensitivity and Specificity Obtained from Magnetic Resonance Relaxation Times

Many ischaemic stroke patients are ineligible for thrombolytic therapy due to unknown onset time. Quantitative MRI (qMRI) is a potential surrogate for stroke timing. Rats were subjected to permanent middle cerebral artery occlusion and qMRI parameters including hemispheric differences in apparent diffusion coefficient, T2-weighted signal intensities, T1 and T2 relaxation times (qT1, qT2) and <i>f</i>1, <i>f</i>2 and <i>V</i>overlapwere measured at hourly intervals at 4.7 or 9.4 T. Accuracy and sensitivity for identifying strokes scanned within and beyond 3 h of onset was determined. Accuracy for <i>V</i>overlap, <i>f</i>2 and qT2 (>90%) was significantly higher than other parameters. At a specificity of 1, sensitivity was highest for <i>V</i>overlap (0.90) and <i>f</i>2 (0.80), indicating promise of these qMRI indices in the clinical assessment of stroke onset time.

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