000309135_sm_Figure.pdf (61.62 kB)
Supplementary Material for: Dendritic Spine Alterations in Neocortical Pyramidal Neurons following Postnatal Neuronal Nogo-A Knockdown
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posted on 2010-10-13, 00:00 authored by Pradhan A.D., Case A.M., Farrer R.G., Tsai S.Y., Cheatwood J.L., Martin J.L., Kartje G.L.The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells.