Supplementary Material for: Berücksichtigung von Wechsel- und Nebenwirkungen bei pflanzlichen Arzneimitteln in deutschen S3-Leitlinien der AWMF

<div>Herbal remedies have a long history in the medical care of</div><div>the German-speaking regions but they are rarely taken into</div><div>account in the development of medical guidelines. In a prestudy,</div><div>our working group analyzed as to how far herbal</div><div>remedies were taken into consideration in the current interdisciplinary</div><div>evidence- and consensus-based S3 medical</div><div>guidelines established by the Association of the Scientific</div><div>Medical Societies (AWMF) in Germany. The aim of this</div><div>study was to analyze to what extent possible side effects</div><div>and interactions of herbal remedies are mentioned in the S3</div><div>medical guidelines. In January 2015, 134 S3 guidelines were</div><div>counted and analyzed. 27.6% (n = 37) of them show 194</div><div>statements summarized under the term ‘phytotherapy’. References</div><div>to side effects and interactions can be found in</div><div>28.4% of the statements (n = 55); 13.9% (n = 27) of these</div><div>references are backed by the literature. 14 of the statements</div><div>deal with nutritional supplements, 11 are statements about</div><div>phytotherapy in general, and 7 summarize at least 2 medical</div><div>plants in 1 statement. Hence, only 23 statements pay attention</div><div>to side effects and interactions of individual medical</div><div>plants; 14 of these are backed by the literature. These results</div><div>do not correspond to the standards required by the</div><div>AWMF, which is due to imprecise terms as well as to the</div><div>insufficiently systematic approach in the search for scientific</div><div>evidence for the safety of medical plants. Here, the Association</div><div>for Phytotherapy may achieve an important contribution</div><div>to quality improvement.</div>