Supplementary Material for: Associations between STAT Gene Polymorphisms and Psoriasis in Northeastern China

2017-04-18T12:01:19Z (GMT) by Zhou J. Li Y. Sun D.
<p><b><i>Background:</i></b> Psoriasis is an autoimmune disease with genetic and environmental factors. Based on the roles of STATs (signaling transducers and activators of transcription) in autoimmune diseases, it is assumed STAT gene polymorphisms are associated with psoriasis. <b><i>Objectives:</i></b> To study the association between STAT gene polymorphisms and psoriasis in the northeastern Chinese population. <b><i>Methods:</i></b> Eight single-nucleotide polymorphisms were genotyped: rs2293152, rs3816769, rs4796793, and rs744166 in STAT3, rs7574865 and rs3024866 in STAT4, and rs324011 and rs3024974 in STAT6, using SNaPshot methods. The genotype, allele, and haplotype frequencies were compared between 400 psoriasis patients and 398 healthy individuals in northeastern China. <b><i>Results:</i></b> rs744166GG in STAT3 and rs7574865TT in STAT4 had higher frequencies in the case than the control group, suggesting these 2 genotypes increase the susceptibility to psoriasis (<i>p</i> < 0.05). Three haplotypes (H3, H6, and H7) were found to be associated with psoriasis in the study (<i>p</i> < 0.05). <b><i>Conclusions:</i></b> These results indicate a role of STAT genes in the pathogenesis of psoriasis.</p>