Supplementary Material for: A Systematic Review of Phytotherapy for Acute Rhinosinusitis

<div>Herbal medicine is a promising alternative in the treatment</div><div>of acute rhinosinusitis (ARS). We performed a systematic</div><div>review for phytopharmaceutical treatments of</div><div>ARS. A computerized search of databases (Cochrane Library,</div><div>PubMed, and Scopus) up to 16 September 2015</div><div>was performed. Randomized controlled trials (RCTs) and</div><div>controlled trials (CTs) were included and assessed using</div><div>the Cochrane risk of bias tool. Seven trials on Pelargonium</div><div>sidoides (EPs 7630, Umckaloabo®), Myrtol (Gelo-</div><div>Myrtol® forte), BNO 1016 (Sinupret® extract), BNO 101</div><div>(Sinupret®), Cyclamen europaeum (Nasodren®), and Esberitox</div><div>® were included. Risk of bias was heterogeneous.</div><div>EPs 7630 appeared to be useful in the treatment of ARS.</div><div>Myrtol showed benefits against a placebo compound,</div><div>and BNO 1016 and BNO 101 might be helpful; however,</div><div>there was little evidence for the effectiveness of Cyclamen</div><div>europaeum and Esberitox®. Herbal medicine might</div><div>be effective for the treatment of ARS, but given the low</div><div>number of clinical trials and the heterogeneous methodological</div><div>quality, further research is necessary.</div>