gnpl_a_1509324_sm8874.pdf (358.99 kB)
Study on chemical constituents of an edible mushroom Volvariella volvacea and their antitumor activity in vitro
journal contribution
posted on 2018-11-20, 09:31 authored by Ping Chen, Hui-Juan Qin, Yuan-Wei Li, Guo-Xu Ma, Jun-Shan Yang, Qi WangPhytochemical investigation of the fruiting body of Volvariella volvacea led to the isolation of a new furanone, 2(5H)-furanone-4-propionic acid named volvafuranone A (1), together with twelve known compounds (2–13). Compounds 2–7, 9–11 were isolated from this mushroom for the first time. The isolated compounds were assessed for their cytotoxicity against four human tumour lines (SGC-7901, PC-3M, MCF-7, HepG-2), and the results showed that compound 2, 3, 12, 13 have significant cytotoxicity with IC50 values of 5.90 μM (HepG-2), 20.72 μM (HepG-2), 27.98 μM (PC-3M) and 23.15 μM (PC-3M), respectively.