5701084_thesis_with_corrections_EmmaDalMaso.pdf (19.47 MB)
Structure and function studies on the Calcitonin Receptor, a Class B1 GPCR
thesis
posted on 2017-12-17, 23:14 authored by EMMA DAL MASOThis thesis examines four common natural variants of the calcitonin receptor (CTR), a GPCR involved in bone remodelling and calcium homeostasis, confirming that receptor splicing can change CTR function, and revealing that two common polymorphism can also influence CTR signalling. Additionally, the CTR was observed to constitutively internalise in different cell systems.
The use of different agonists, some of which biased, has allowed to start exploring the mechanistic basis of how ligands control CTR function, showing that different ligands distinctly activate the CTR through unique interactions with the receptor, and that different pathways are controlled by distinct portions of the receptor.
History
Campus location
AustraliaPrincipal supervisor
Denise Laura WoottenAdditional supervisor 1
Sebastian FurnessAdditional supervisor 2
Patrick SextonAdditional supervisor 3
David ThalYear of Award
2017Department, School or Centre
Drug Discovery BiologyCourse
Doctor of PhilosophyDegree Type
DOCTORATEFaculty
Faculty of Pharmacy and Pharmaceutical SciencesUsage metrics
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Keywords
calcitonin receptorgpcrreceptor traffickinginternalisationMutagenesis, Site-DirectedModels, MolecularCyclic AMPcalcium/metabolismcalcitonin peptidebiased agonismPeptides/chemistry/pharmacologyCV-1COS-7osteoclastsBRETArrestin recruitmentreceptor activationReceptors and Membrane BiologyCell BiologyProtein Trafficking
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