figshare
Browse

Embargoed and Restricted Access

Reason: Under embargo until August 2023. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Structural and Functional Analysis of Interleukin-37 Signalling

thesis
posted on 2017-08-07, 00:06 authored by LAURA PRUDENCE D'ANDREA
The interleukin-1 family of cytokines are typically pro-inflammatory proteins that work together to regulate host defence. Interleukin-37 is a recently identified cytokine that is different from its other family members, since it is a broad-spectrum inhibitor of inflammation. We solved its structure at high resolution and discovered that it had a unique conformation compared to other family members. Structure-guided mutational analysis enabled generation of different forms of interleukin-37. These forms exhibited increased anti-inflammatory activity in collaborative cell-based assays and mice models compared to wild-type. These results suggest interleukin-37 and its mutants could be key targets for therapeutic development.

History

Principal supervisor

Andrew Ellisdon

Additional supervisor 1

James Whisstock

Year of Award

2017

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

Usage metrics

    Faculty of Medicine, Nursing and Health Sciences Theses

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC