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Reason: Under embargo until August 2023. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Structural and Functional Analysis of Interleukin-37 Signalling
thesis
posted on 2017-08-07, 00:06 authored by LAURA PRUDENCE D'ANDREAThe interleukin-1 family of cytokines are typically pro-inflammatory proteins that work together to regulate host defence. Interleukin-37 is a recently identified cytokine that is different from its other family members, since it is a broad-spectrum inhibitor of inflammation. We solved its structure at high resolution and discovered that it had a unique conformation compared to other family members. Structure-guided mutational analysis enabled generation of different forms of interleukin-37. These forms exhibited increased anti-inflammatory activity in collaborative cell-based assays and mice models compared to wild-type. These results suggest interleukin-37 and its mutants could be key targets for therapeutic development.