Structural and Functional Analysis of Chemokine Receptor CCR2 and its Cognate Chemokines

2017-08-17T04:21:54Z (GMT) by ZIL E HUMA
An important aspect of inflammation, the body’s response to injury or infection, is the migration of white blood cells into the affected tissues. White blood cell migration is controlled by proteins called chemokines, which are produced in the damaged tissues and interact with receptors on the surface of the blood cells. This project investigated molecular details of how a receptor can respond differently to distinct chemokine signals. The results of this study will help to guide future development of medicines to control white blood cell migration during inflammatory diseases like atherosclerosis, diabetes and obesity.