ol9b04008_si_001.pdf (15.46 MB)
Structural Revision and Absolute Configuration of Burnettramic Acid A
journal contribution
posted on 2019-12-12, 19:06 authored by Jiao Li, Minghua Chen, Xiaomeng Hao, Shasha Li, Fang Li, Liyan Yu, Chunling Xiao, Maoluo GanThe recently discovered antibiotic burnettramic acid
A (1) and three new congeners, burnettramic acids C–E
(2–4), were identified from the co-cultures
of
two marine Aspergillus strains. The structure of
burnettramic acid A was revised on the basis of reinterpretation of
the nuclear magnetic resonance (NMR) data and chemical derivatization.
The full absolute configurations of burnettramic acids were established
using the Mosher ester method and Marfey’s analysis, combined
with density functional theory calculation of NMR and electric circular
dichroism data.