ijds_a_1484404_sm4182.docx (3.77 MB)
Straightforward Preparation of Naphtodianthrone-Rich Ethanolic Extracts from Wild St. John’s Wort
journal contribution
posted on 2018-10-31, 23:50 authored by Carmen Elena Ţebrencu, Tanţa-Verona Iordache, Elena Ionescu, Ruxandra Mihaela Creţu, Ana-Mihaela Florea, Sandu Teodor, Steluta Apostol, Anamaria Zaharia, Anita-Laura Radu, Andrei SârbuSeparation of naphtodianthrones (NTs) from Hypericum perforatum L. (aerial part of St. John’s Wort) is still topical due to some hard-to-beat medicinal attributes of these bioactive compounds. Unfortunately, their low bioavailability (0.06%–0.4%) complicates the extraction process. Therefore, developing straightforward and lower-cost methodologies for NT separation is still a priority. In support of this purpose, for preparing NT formulations from flowers and leaves of wild St. John’s Wort (hyperici herba), a cutoff preparative methodology is described herein. Combining Soxhlet extraction and reflux extraction, some concentrated and rather pure NT ethanolic-based formulations without chlorophyl and grease were obtained.