op5b00148_si_001.pdf (1.42 MB)
Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Benzylic Ethers with Isotopically-Labeled Grignard Reagents
journal contribution
posted on 2015-10-16, 00:00 authored by David
D. Dawson, Elizabeth R. JarvoIn
this manuscript we highlight the potential of stereospecific
nickel-catalyzed cross-coupling reactions for applications in the
pharmaceutical industry. Using an inexpensive and sustainable nickel
catalyst, we report a gram-scale Kumada cross-coupling reaction. Reactions
are highly stereospecific and proceed with inversion at the benzylic
position. We also expand the scope of our reaction to incorporate
isotopically labeled substituents.