Stereoselective Synthesis of the Cytotoxic Macrolide FD-891<sup>†</sup>
2006-06-22T00:00:00Z (GMT) by
A total synthesis of the naturally occurring, cytotoxic macrolide FD-891 is described. Three fragments were first stereoselectively constructed using mainly asymmetric aldol and allylation reactions. The complete framework was then assembled using two Julia−Kocienski olefinations to connect the three fragments and a Yamaguchi reaction to close the macrolactone ring.
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