Stereoselective Bioreduction of Bulky-Bulky Ketones by a Novel ADH from <i>Ralstonia</i> sp.

Ketones with two bulky substituents, named bulky-bulky ketones, as well as less sterically demanding ketones were successfully reduced to the corresponding optically highly enriched alcohols using a novel identified recombinant short-chain alcohol dehydrogenase RasADH from <i>Ralstonia</i> sp. DSM 6428 overexpressed in <i>E. coli</i>.