Fig 3.TIF (8.71 MB)
Stereogram of the interaction between glucocorticoid receptor ligand binding domain and dexamethasone.
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posted on 2016-10-13, 17:43 authored by Henry Reyer, Siriluck Ponsuksili, Ellen Kanitz, Ralf Pöhland, Klaus Wimmers, Eduard MuraniStructural models of helix 3 to helix 7 of the ligand binding domain of the wild-type Ala610 (A) and the mutated Val610 (B) receptor variants are shown. The distances of the alternative alanine (blue) and valine (red) residue at amino acid position 610 with the two methyl carbon atoms of Val654, and the carbon C-6 and C-7 positions of the ligand dexamethasone (green), are indicated in angstroms (Å).
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GR responsivenessreceptor-ligand interactionsGR-binding studiesLigand Binding Domainligand bindinggain-of-function substitutionVal 610 GRbinding distancesHelix 5Ala 610Val substitutionHPA axis activitycortisol productionreceptor-ligand interactionglucocorticoid receptorGR ligandsneuroendocrine stress responsetrait locusGlucocorticoid Receptor Enhances Receptor-Ligand Interactionmediates feedback regulationnon-glucocorticoid steroidsNatural Mutationprotein structure predictionphenotypic effectsAla 610Valligand binding pocketligand binding domain
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