Stereo views of cocrystal structures-Ahmed-Belkacem et al.docx (46.6 MB)

Stereo views of cocrystal structures of cyclophilin inhibitors with cyclophilin D

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posted on 2016-07-18, 12:56 authored by Jean-Michel PawlotskyJean-Michel Pawlotsky, Abdelhakim Ahmed-Belkacem, Nazim Ahnou, Quentin Nevers, Muriel Gelin, Yannick Bessin, Rozenn Brillet, Olivier Cala, Dominique Douguet, William Bourguet, Isabelle Krimm, Jean-Francois Guichou

Cocrystal structures of new non-peptidic, small-molecule cyclophilin inhibitors with cyclophilin D. Stereo views of a section of the electron density maps. Cross-eye stereo views of sections of the 2Fo-Fc map (contoured at 1σ) show electron density of each compound.

Funding

French Infrastructure for Integrated Structural Biology (FRISBI) ANR-10-INSB-05-01, Fonds Européen de Développement Économique et Régional (FEDER) N°48748, Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) and Fondation pour la

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Keywords

cyclophilin cyclophilin inhibitors fragment-based drug discovery small-molecule, non-peptidic compound antiviral agent Virology Structural Chemistry and Spectroscopy

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CC BY 4.0

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