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Stereo view of piceatannol bound in GAPDH active center.

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posted on 2018-01-03, 18:39 authored by Joanna Gerszon, Eligiusz Serafin, Adam Buczkowski, Sylwia Michlewska, Jakub Antoni Bielnicki, Aleksandra Rodacka

Covalent binding between nucleophilic thiol group in Cys149 and piceatannol at the 2-C position of the aromatic ring B forms the protein-piceatannol adduct.

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    oxidative modificationsnucleophilic cysteine residueglyceraldehyde -3-phosphate dehydrogenase Glyceraldehyde -3-phosphate dehydrogenaseGAPDH aggregation11 ligand binding positionsITCGAPDH piceatannol blocks cysteine residuepiceatannol decreases GAPDH activityreactive cysteine residue

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