Spiro Meroterpenoids from <i>Ganoderma applanatum</i>
2016-12-20T14:05:04Z (GMT) by
Spiroapplanatumines A–Q (<b>1</b>–<b>12</b>, <b>14</b>–<b>16</b>, <b>18</b>, and <b>20</b>), new spiro meroterpenoids respectively bearing a 6/5/7 or 6/5/5 ring system, along with three known compounds, spirolingzhines A, B, and D, were isolated from the fruiting bodies of the fungus <i>Ganoderma applanatum</i>. Their structures including absolute configurations were assigned by using spectroscopic methods, ECD and <sup>13</sup>C NMR calculations, and single-crystal X-ray diffraction analysis. Biological evaluation of all the compounds disclosed that compounds <b>7</b> and <b>8</b> inhibited JAK3 kinase with IC<sub>50</sub> values of 7.0 ± 3.2 and 34.8 ± 21.1 μM, respectively.