Spectral and electrochemical investigation of <i>p</i>-sulfonatocalix[4]arene-stabilized vitamin E aggregation

<p>The host–guest interaction of α-tocopherol (vitamin E) with <i>p</i>-sulfonatocalix[4]arene (<i>p</i>-SC4) in solution state is studied using emission and cyclic voltammetric techniques. The lipid soluble α-tocopherol (α-T) forms a solid complex with <i>p</i>-SC4. FTIR and NMR spectral analysis of the solid complex reveals the tight packing of α-T inside the cavity of <i>p</i>-SC4. The structural deformation is confirmed by XRD analysis. SEM images differentiate the highly porous gel like structure of vitamin E aggregate and the solid structure of the host–guest complex prepared. NOESY spectra confirm the tight penetration of α-T within the hydrophobic cavity of <i>p</i>-SC4.</p>