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Solvent and substituent effects on the conversion of 4-methoxypyridines to N-methyl-4-pyridones

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Version 2 2020-08-24, 13:21
Version 1 2017-03-17, 15:21
journal contribution
posted on 2017-03-17, 15:21 authored by Xiao Yi, Jing Chen, Xiuling Xu, Yongmin Ma

In the reaction of 4-methoxypyridine derivatives with alkyl iodides in the presence or absence of solvent, not only the pyridinium ions but also the related 1-methylpyridones are produced. The presence of solvent favors the formation of the 1-methylpyridone. Electron withdrawing groups on the pyridine ring also favor this conversion. A possible mechanism is presented.

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