Six month-old male whole body glucose, insulin and pyruvate tolerance.

Whole body tolerance tests were completed on fasted 6 month-old male wildtype (WT), aromatase knockout (KO) and 2.5 µg/kg 17β-estradiol-treated KO (KOE). (a) Glucose tolerance test and corresponding area under curve; (b) insulin tolerance test and corresponding area under curve; (c) pyruvate tolerance test and corresponding area under curve. Data are presented from replicate analysis (n =  shown on corresponding bar) as the mean ± SD. *p<0.05, **p<0.01, versus expression in age-matched WT samples and #p<0.05 and ##p<0.01 versus KO samples