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Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re6Q8}(CN)6]4– (Q = S, Se, Te)
journal contribution
posted on 2017-10-08, 16:29 authored by Anastasiya O. Solovieva, Kaplan Kirakci, Anton A. Ivanov, Pavel Kubát, Tatiana N. Pozmogova, Svetlana M. Miroshnichenko, Elena V. Vorontsova, Anton V. Chechushkov, Kristina E. Trifonova, Maria S. Fufaeva, Evgeniy I. Kretov, Yuri V. Mironov, Alexander F. Poveshchenko, Kamil Lang, Michael A. ShestopalovOctahedral rhenium cluster complexes
have recently emerged as relevant building blocks for the design of
singlet oxygen photosensitizing materials toward biological applications
such as blue-light photodynamic therapy. However, their singlet oxygen
generation ability as well as biological properties have been studied
only superficially. Herein we investigate in detail the singlet oxygen
photogeneration, dark and photoinduced cytotoxicity, cellular uptake
kinetics, cellular localization and in vitro photoinduced oxidative
stress, and photodynamic cytotoxicity of the series of octahedral
rhenium cluster complexes [{Re6Q8}(CN)6]4–, where Q = S, Se, Te. Our results demonstrate
that the selenium-containing complex possesses optimal properties
in terms of absorption and singlet oxygen productivity. These features
coupled with the cellular internalization and low dark toxicity lead
to the first photoinduced cytotoxic effect observed for a molecular
[{M6Q8}L6] complex, making it a promising
object for further study in terms of blue-light PDT.
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Rephotodynamic cytotoxicitytermsinglet oxygen productivitysinglet oxygen photogenerationblue-light photodynamic therapyblue-light PDTbuilding blockssinglet oxygen generation abilitySinglet Oxygen Productionphotoinduced cytotoxicityCNphotoinduced cytotoxic effectuptake kineticsSephotoinduced oxidative stressTeBiological ActivityOctahedral rhenium cluster complexessinglet oxygen photosensitizing materials
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