Simulation-based power curves.

<p>Left panel: Power versus relative risk ratio (RRR) for different sample sizes, minor allele frequency (MAF) = 0.2, significance level = 0.05. Middle panel: Power versus RRR for different MAFs, total sample size = 500. Right panel: Power versus RR or RRR, as applicable to each effect type, MAF = 0.2, total sample size = 500. Note that the black curve with full squares is identical in all panels (based on a total of 500 trios, MAF = 0.2, and PoOxE). In the PoOxE analysis, we have varied the RR of the maternal allele with exposure status.</p>