jo5b02594_si_002.cif (13.62 kB)
Silver-Catalyzed Decarboxylative Addition/Cyclization of Activated Alkenes with Aliphatic Carboxylic Acids
dataset
posted on 2016-02-04, 15:53 authored by Xiao-Feng Xia, Su-Li Zhu, Chao Chen, Haijun Wang, Yong-Min LiangA silver-catalyzed
decarboxylative addition/aryl migration/desulfonylation
of N-phenyl-N-(phenylsulfonyl)methacrylamide
with primary, secondary, and tertiary carboxylic acids was described.
The protocol provides an efficient approach for the synthesis of α-all-carbon
quaternary stereocenters amides and isoquinolinediones. It was proposed
that the radical generated from the silver-catalyzed decarboxylation
was involved in the sequence reaction.