Sharing of alpha out-of-frame TCR clonotypes as a function of clonal abundance.
figure
posted on 2017-07-06, 17:25 authored by Mikhail V. Pogorelyy, Yuval Elhanati, Quentin Marcou, Anastasiia L. Sycheva, Ekaterina A. Komech, Vadim I. Nazarov, Olga V. Britanova, Dmitriy M. Chudakov, Ilgar Z. Mamedov, Yury B. Lebedev, Thierry Mora, Aleksandra M. WalczakThe normalized number of shared out-of-frame alpha CDR3 nucleotide sequences between two individuals is showed as a function of clonotype abundance (e.g. normalized sharing for 2000 most abundant clones from both repertoires, 4000 most abundant, etc.), and compared to the amount of sharing that would be expected by chance (blue curve), taking into account the variable fraction of zero-insertion clonotypes as a function of their abundance. Data and predictions show excellent quantitative agreement (inset), with one fitting parameter. Error bars show one standard deviation.
