Sesquiterpenes from <i>Chloranthus japonicus</i>

Eight new sesquiterpene lactones (chlorajapolides A−E, <b>1</b>−<b>5</b>, chlorajaposide, <b>6</b>, chlorajaponol, <b>7</b>, and chloraeudolide, <b>8</b>) were isolated from an ethyl acetate-soluble partition of the ethanol extract of the whole plants of <i>Chloranthus japonicus</i>. The structures and relative configurations of <b>1</b>−<b>8</b> were established on the basis of spectroscopic data analysis. All isolates obtained were evaluated for their cytotoxic activity against a small panel of cancer cell lines.