Sesquiterpenes from Chloranthus japonicus

Eight new sesquiterpene lactones (chlorajapolides A−E, 15, chlorajaposide, 6, chlorajaponol, 7, and chloraeudolide, 8) were isolated from an ethyl acetate-soluble partition of the ethanol extract of the whole plants of Chloranthus japonicus. The structures and relative configurations of 18 were established on the basis of spectroscopic data analysis. All isolates obtained were evaluated for their cytotoxic activity against a small panel of cancer cell lines.