Fig 1.tif (342.43 kB)
Sequence alignment of peptide ligands binding the Mdm2/Mdm4 N-terminal domains.
figure
posted on 2017-12-11, 18:23 authored by Sharon Min Qi Chee, Jantana Wongsantichon, Jiawei Siau, Dawn Thean, Fernando Ferrer, Robert C. Robinson, David P. Lane, Christopher J. Brown, Farid J. GhadessyShaded residues are the conserved interacting residues (F19, W23 and L26) derived from p53. Xr and Xs represent (S)-2-(4′pentenyl) alanine and (S)-2-(7′-octenyl) alanine (coupled by olefin metathesis).
