bm400626w_si_001.pdf (2.06 MB)
Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer
journal contribution
posted on 2013-08-12, 00:00 authored by Tzu-Yu Liu, Waleed
M. Hussein, Zhongfan Jia, Zyta M. Ziora, Nigel A. J. McMillan, Michael J. Monteiro, Istvan Toth, Mariusz SkwarczynskiDendrimers are structurally well-defined,
synthetic polymers with
sizes and physicochemical properties often resembling those of biomacromolecules
(e.g., proteins). As a result, they are promising candidates for peptide-based
vaccine delivery platforms. Herein, we established a synthetic pathway
to conjugate a human papillomavirus (HPV) E7 protein-derived peptide
antigen to a star-polymer to create a macromolecular vaccine candidate
to treat HPV-related cancers. These conjugates were able to reduce
tumor growth and eradicate E7-expressing TC-1 tumors in mice after
a single immunization, without the help of any external adjuvant.