jo300806y_si_001.pdf (1.39 MB)
Selective “One-Pot” Synthesis of Functionalized Cyclopentenones
journal contribution
posted on 2012-07-20, 00:00 authored by Teresa Varea, Ana Alcalde, Carolina López de Dicastillo, Carmen Ramírez de Arellano, Fernando P. Cossío, Gregorio AsensioDouble addition (1,2–1,4) of vinyl magnesium bromide
to
squaric acid derivatives allows the preparation of polyoxygenated
cyclopentenones (8) in a “one-pot” procedure. The reaction
occurs through the intermediate formation of octatetraenes (6). Protonation
of this latter intermediate at −78 °C with TFE occurs
selectively at the vinyl CH2 closer to the metallic centers.
DFT studies of the cyclization step justify the observed diastereoselectivity.