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Screening Platform for Identification of Suitable Monomer Mixtures Able To Form Thin-Film Coatings on Polyurethanes by UV-Initiated Free Radical Polymerization
journal contribution
posted on 2019-11-08, 22:29 authored by Christian Andersen, Niels Jørgen Madsen, Anders E. DaugaardScreening platforms have become a
valuable tool for exploring large
libraries of surface chemistries helping the discovery of new materials
for especially biological applications. Methods applied in these platforms,
however, are mainly based on inert bulk synthesis at picoliter scale,
resulting in noncovalently attached molecules on stiff glass substrates.
This is a poor representation of a potential final product from an
industrial perspective. To overcome this, we have developed a screening
platform capable of conducting UV-initiated free radical polymerization
(FRP) directly onto a flexible polyurethane under ambient conditions.
The platform allows for the study of solvent and monomer effects under
industrially relevant conditions and was used to graft a series of
homo- and copolymer systems (2,2,2-trifluoroethyl methacrylate (TrFEMA), N-isopropylacrylamide (NIPAAm), diethylene glycol
methyl ether methacrylate-co-poly(ethylene glycol)
methyl ether methacrylate, (MDEGMA-co-MPEGMA), and
acrylic acid (AA)), which was confirmed by both water contact angle
(WCA) and X-ray photoelectron spectroscopy (XPS) analysis. The versatility
of the system was further demonstrated through investigation of terpolymer
systems and direct evaluation of their antifouling properties using
a fluorescein-labeled bovine serum albumin (BSA).
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UV-Initiated Free Radical Polymerization Screening platformsambient conditionsXPSacrylic acidantifouling propertiesglycolsurface chemistriesscreening platformMDEGMAX-ray photoelectron spectroscopyMPEGMApicoliter scaleterpolymer systemsbulk synthesisBSAFRPglass substratesmonomer effectsmethyl ether methacrylatewater contact angleAAScreening PlatformWCAserum albuminSuitable Monomer Mixtures AbleForm Thin-Film Coatings
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