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Schematic representation of muscle wasting in AP-injected HSA-Fv2E-PERK Tg mouse.

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posted on 2017-06-23, 17:55 authored by Masato Miyake, Masashi Kuroda, Hiroshi Kiyonari, Kenji Takehana, Satoshi Hisanaga, Masatoshi Morimoto, Jun Zhang, Miho Oyadomari, Hiroshi Sakaue, Seiichi Oyadomari

(A) In normal condition, hormones, such as insulin and IGF-1, stimulate protein synthesis through enhancing the formation of the 43S and 48S preinitiation complexes, which are essential for muscle maintenance. (B) In muscle wasting conditions, signals regulating the formation of the 43S and 48S preinitiation complex were disturbed. (C) In AP-injected HSA-Fv2E-PERK Tg mouse, inhibition of the formation of 43S preinitiation complex by eIF2 phosphorylation led to muscle atrophy due to reduced protein synthesis, along with a counter-regulatory increase in 48S preinitiation complex.

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