Fig 1.tif (1.16 MB)
SNc DA neuron physiology.
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posted on 2016-12-30, 18:34 authored by Chad M. Estep, Daniel J. Galtieri, Enrico Zampese, Joshua A. Goldberg, Lars Brichta, Paul Greengard, D. James Surmeier(A) 2P reconstruction of SNc DA neuron. (B) Left, normal pacemaking of a SNc DA neuron. Middle, TTX (1 μM) application uncovered slow oscillatory potential (SOP). Right, 5 μM baclofen application hyperpolarized the cell. (C) Summary of hyperpolarization due to application of 5 μM baclofen (n = 8, median = -25.24 mV). (D) Sustained uncaging of 5 μM RuBi-GABA in the presence of 25 μM gabazine (to block GABAA receptors) hyperpolarized cells in a manner similar to that seen following baclofen application. (E) Summary of hyperpolarization due to sustained 5 μM RuBi-GABA uncaging (n = 7, median = -11.71 mV).
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calcium-activated KGABA B receptor activationpause-burst patternburst spikingGABA B receptors hyperpolarized SNc DA neuronsSustained stimulationGABA B Receptors Suppresses SK Channel Currentsspike generationprotein kinaseTransient ActivationSK channel activity increasesGABA B receptorsSubstantia Nigra Pars Compacta Dopaminergic Neurons Dopaminergicpostsynaptic effectsGABAergic neuronspatch recordingsadenylyl cyclaseadult mouse SNc DA neuronssubstantia nigra pars compactaSNc DA neurons
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