SI2-SSE: Collaborative Research: Integrated Tools for DNA Nanostructure Design and Simulation

Programming matter with nanometer precision is the ultimate goal of materials science and engineering. Over the past decade, computer modeling has been leading the development of structural DNA nanotechnology, transcribing target structure designs into the language of DNA sequence. This project will develop software interfaces between two classes of molecular design programs to bridge a conceptual gap between mathematical rules governing DNA self-assembly and the physical laws governing the real-world behavior of DNA. The software will dramatically simplify the DNA nanostructure design process, giving materials scientists and engineers access to DNA self-assembly technology to fulfill their research and design needs.