ja404695t_si_001.pdf (2.99 MB)
Ruthenium-Catalyzed Redox-Neutral and Single-Step Amide Synthesis from Alcohol and Nitrile with Complete Atom Economy
journal contribution
posted on 2013-08-14, 00:00 authored by Byungjoon Kang, Zhenqian Fu, Soon Hyeok HongA completely
atom-economical and redox-neutral catalytic amide
synthesis from an alcohol and a nitrile is realized. The amide C–N
bond is efficiently formed between the nitrogen atom of nitrile and
the α-carbon of alcohol, with the help of an N-heterocyclic
carbene-based ruthenium catalyst, without a single byproduct. A utility
of the reaction was demonstrated by synthesizing 13C or 15N isotope-labeled amides without involvement of any separate
reduction and oxidation step.