Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides

Zhang, Li; Chen, Xinguo; Xue, Peng; Sun, Herman H. Y.; Williams, Ian D.; Sharpless, K. Barry; Fokin, Valery V.; Jia, Guochen

doi:10.1021/ja054114s.s005

ja054114s_si_005.pdf (1.95 MB)

Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides

journal contribution

posted on 2005-11-23, 00:00 authored by Li Zhang, Xinguo Chen, Peng Xue, Herman H. Y. Sun, Ian D. Williams, K. Barry Sharpless, Valery V. Fokin, Guochen Jia

Cp*RuCl(PPh₃)₂ is an effective catalyst for the regioselective “fusion” of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.