Romidepsin, Panobinostat, (+)-JQ1, and PTC-209 induce global KSHV gene expression.

KSHV whole genome transcriptional profiling was performed on BCBL-1 cells treated with DMSO or 1 μM Romidepsin or Panobinostat for 48 hours (A), or with 10μM (+)-JQ1 or PTC-209 for 120 hours (B). mRNA levels of viral genes were normalized to the mRNA levels of multiple cellular housekeeping genes to yield dCt as a measure of relative expression. Higher transcript expression levels are indicated by red and lower expression levels by blue.