Role of biological sex in cardiac cellular composition and cellular communication

Cardiovascular disease is the biggest killer of people in the world. While it affects both men and women, men have a higher chance of suffering from cardiovascular disease compared to women and research is urgently need to understand why this is the case. During my candidature, I found that males and females are fundamentally different to each other at the cellular level and the cellular differences between the sexes are regulated by sex hormones. My research uncovers the role of biological sex in the heart and provides novel avenues of investigation to understand sex differences in cardiovascular disease.