ol052797a_si_002.cif (17.67 kB)
Ring-Opening Cyclization of Alkylidenecyclopropyl Ketones with Amines. An Efficient Synthesis of 2,3,4-Trisubstituted Pyrroles
dataset
posted on 2006-03-02, 00:00 authored by Lianghua Lu, Guofei Chen, Shengming MaAn efficient synthesis of 2,3,4-trisubstituted pyrroles via intermolecular cyclization of alkylidenecyclopropyl ketones with amines was observed.
The addition of anhydrous MgSO4 improved the yields of the products 3. A possible mechanism involving the distal cleavage of the C−C bond
of cyclopropane ring was proposed.