am300918s_si_001.pdf (565.13 kB)
Rigidity Guided Cell Attachment on Inkjet-Printed Patterns
journal contribution
posted on 2012-07-25, 00:00 authored by Ying-Chih Liao, Yun-Ting Ma, Chi-Hui Huang, Jiashing Yu, Hao-Ming HsiaoA new approach is presented to control cell attachment
behavior
on biocompatible substrates. Multiple layers of polylactic acid (PLA)
were inkjet-printed on dry alginate films to create composite surfaces
with rigidity variation. The printed films were submerged in cell
culture medium and fibroblast 3T3-L1 cells were cultured on the printed
films. 3T3-L1 cells were found to preferentially adhere on PLA surfaces
with higher rigidity. The same approach was also used to create various
cell attachment patterns. This study provides a new methodology to
fabricate biodegradable matrix for favorable cell adhesion or patterning.