Rh-Catalyzed One-Pot Sequential Asymmetric Hydrogenation of α‑Dehydroamino Ketones for the Synthesis of Chiral Cyclic <i>trans</i>-β-Amino Alcohols

Catalyzed by a rhodium complex of P-stereogenic diphosphine ligand (<i>R</i>)-2-<i>tert</i>-butylmethylphosphino-3-(di-<i>tert</i>-butylphosphino)­quinoxaline ((<i>R</i>)-<b>3H-QuinoxP</b>*), five-membered cyclic α-dehydroamino ketones bearing endocyclic vinyl and endocyclic keto-carbonyl groups were sequentially hydrogenated to give chiral cyclic <i>trans</i>-β-amino alcohols with two contiguous stereocenters in quantitative conversions, excellent enantioselectivities and good diastereoselectivities.