ol6b00212_si_001.pdf (4.39 MB)
Rh-Catalyzed One-Pot Sequential Asymmetric Hydrogenation of α‑Dehydroamino Ketones for the Synthesis of Chiral Cyclic trans-β-Amino Alcohols
journal contribution
posted on 2016-03-08, 02:13 authored by Qiupeng Hu, Jianzhong Chen, Zhenfeng Zhang, Yangang Liu, Wanbin ZhangCatalyzed
by a rhodium complex of P-stereogenic diphosphine ligand
(R)-2-tert-butylmethylphosphino-3-(di-tert-butylphosphino)quinoxaline ((R)-3H-QuinoxP*), five-membered cyclic α-dehydroamino
ketones bearing endocyclic vinyl and endocyclic keto-carbonyl groups
were sequentially hydrogenated to give chiral cyclic trans-β-amino alcohols with two contiguous stereocenters in quantitative
conversions, excellent enantioselectivities and good diastereoselectivities.