Resveratrol Oligomers from <i>Vatica albiramis</i>

Five new stilbenoids, vatalbinosides A−E (<b>1</b>−<b>5</b>), and 13 known compounds (<b>6</b>−<b>18</b>) were isolated from the stem of <i>Vatica albiramis</i>. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (−)-hopeaphenol (<b>6</b>), vaticanol C (<b>13</b>), and stenophyllol C (<b>14</b>), were identified as strong inhibitors of MMP-1 production.