np1002675_si_001.pdf (2.11 MB)
Resveratrol Oligomers from Vatica albiramis
journal contribution
posted on 2010-09-24, 00:00 authored by Naohito Abe, Tetsuro Ito, Kenji Ohguchi, Minori Nasu, Yuichi Masuda, Masayoshi Oyama, Yoshinori Nozawa, Masafumi Ito, Munekazu IinumaFive new stilbenoids, vatalbinosides A−E (1−5), and 13 known compounds (6−18) were isolated from the stem of Vatica albiramis. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (−)-hopeaphenol (6), vaticanol C (13), and stenophyllol C (14), were identified as strong inhibitors of MMP-1 production.