pone.0169086.g001.tif (394.37 kB)
Response to tetanus toxoid is broad but characterized by a high degree of immunodominance.
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posted on 2017-01-12, 17:30 authored by Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M. Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, Cecilia S. Lindestam Arlehamn(A) Epitopes ranked on the basis of magnitude of response. Dotted lines indicate the top 10 (65% of total response) and top 28 (90% of total response) epitopes. (B) Breadth of response indicated by proportion of donors who respond to the specified number of epitopes. (C) Epitopes plotted as a function of the response frequency. Black line indicates the 19 epitopes that are recognized by 10% or more.
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TT responsesT cell epitope repertoireTT epitope poolHuman Epitopes RecognizedT Cell Responseseffector memory T cellsCD 4Detect Ex Vivo Tetanus CD 4acellular DTaP formulationHLA Class II binding28 epitopes accountingcytokine-independent Activation Induced MarkerAIMacellular vaccine formulationHLA binding predictions re-identified
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