Response to tetanus toxoid is broad but characterized by a high degree of immunodominance.

<p>(A) Epitopes ranked on the basis of magnitude of response. Dotted lines indicate the top 10 (65% of total response) and top 28 (90% of total response) epitopes. (B) Breadth of response indicated by proportion of donors who respond to the specified number of epitopes. (C) Epitopes plotted as a function of the response frequency. Black line indicates the 19 epitopes that are recognized by 10% or more.</p>