Resolution of racemic Vigabatrin using tartaric acid

An efficient and simple resolution methodology for the preparation of (S)- and (R)-Vigabatrin has been developed. In addition, a method of preparation for the novel compounds Vigabatrin-l-tartarate and Vigabatrin-d-tartarate is also described. The title compounds have been synthesized via resolution of Vigabatrin using commercially available l-(+)- and d-(−)-tartaric acids respectively.