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Resin-Bound Dynamic Combinatorial Chemistry

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journal contribution
posted on 2006-04-27, 00:00 authored by Brian R. McNaughton, Benjamin L. Miller
Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of-concept experiments demonstrating a new technique termed resin-bound DCC (RB-DCC), which provides a solution to this problem.

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