Resetting Immunoglobulin Paratope Memory for the Recognition of Antigenically Varying Dengue Viral Serotypes to Prevent Antibodydependent Enhancement of Infection

The Dengue Virus (DENV) does not have any treatment or effective vaccine that can be used to target the infection. Development of an effective treatment or vaccine is difficult due to Antibody Dependent Enhancement (ADE) of infection. As antibodies are responsible for recognition of an infection, we attempt to understand the mechanism by which antibody memory is created. Based on a hypothesis for the process by which antibody memory is developed, we identify a method by which the memory can be reset to be antigen non-specific, where the antibody’s Paratope is unable to recognize the DENV antigen and reacts by forming a new structure in the Paratope.