Reproducibility of binding potentials estimated using HYDECA, LEGA, and 2TCM.
Average plus standard deviation (across test-retest pairs of scans within each tracer) test-retest percent difference PDBPP values calculated in each of the considered region for [11C]DASB (left) and [11C]CUMI-101 (right), using BPP based on VND from HYDECA, BPP based on VT-RR,LEGA, BPP calculated directly from the 2TCM kinetic rates, and BPP based on VT-RR,2TCM (top). Corresponding values for the test-retest percent difference PDBPND (bottom). Vertical axes are reported in logarithmic scale to allow for easier visualization of the direct 2TCM results based on 2TCM kinetic rates. Statistically significant comparisons (p-value ≤ 0.05) are indicated. AMY: amygdala; CIN: cingulate; DCA: dorsal caudate; HIP: hippocampus; OCC: occipital lobe; TEM: temporal lobe; VST: ventral striatum; PDBPP: percent difference for BPP; PDBPND: percent difference for BPND; VND: non-displaceable distribution volume; VT-RR,LEGA: tracer total distribution volume in the non-ideal reference region estimated using LEGA; LEGA: Likelihood Estimation in Graphical Analysis; 2TCM: two-tissue compartment model; VT-RR,2TCM: racer total distribution volume in the non-ideal reference region estimated using 2TCM.