Reproducibility of binding potentials estimated using HYDECA, LEGA, and 2TCM.

<p>Average plus standard deviation (across test-retest pairs of scans within each tracer) test-retest percent difference PD<sub>BPP</sub> values calculated in each of the considered region for [<sup>11</sup>C]DASB (left) and [<sup>11</sup>C]CUMI-101 (right), using BP<sub>P</sub> based on V<sub>ND</sub> from HYDECA, BP<sub>P</sub> based on V<sub>T-RR,LEGA</sub>, BP<sub>P</sub> calculated directly from the 2TCM kinetic rates, and BP<sub>P</sub> based on V<sub>T-RR,2TCM</sub> (top). Corresponding values for the test-retest percent difference PD<sub>BPND</sub> (bottom). Vertical axes are reported in logarithmic scale to allow for easier visualization of the direct 2TCM results based on 2TCM kinetic rates. Statistically significant comparisons (p-value ≤ 0.05) are indicated. AMY: amygdala; CIN: cingulate; DCA: dorsal caudate; HIP: hippocampus; OCC: occipital lobe; TEM: temporal lobe; VST: ventral striatum; PD<sub>BPP</sub>: percent difference for BP<sub>P</sub>; PD<sub>BPND</sub>: percent difference for BP<sub>ND</sub>; V<sub>ND</sub>: non-displaceable distribution volume; V<sub>T-RR,LEGA</sub>: tracer total distribution volume in the non-ideal reference region estimated using LEGA; LEGA: Likelihood Estimation in Graphical Analysis; 2TCM: two-tissue compartment model; V<sub>T-RR,2TCM</sub>: racer total distribution volume in the non-ideal reference region estimated using 2TCM.</p>