am7b02002_si_003.avi (704.63 kB)
Regulation of Drug Release by Tuning Surface Textures of Biodegradable Polymer Microparticles
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posted on 2017-04-03, 00:00 authored by Mubashir Hussain, Jun Xie, Zaiyan Hou, Khurram Shezad, Jiangping Xu, Ke Wang, Yujie Gao, Lei Shen, Jintao ZhuGenerally, size,
uniformity, shape, and surface chemistry of biodegradable polymer
particles will significantly affect the drug-release behavior in vitro
and in vivo. In this study, uniform poly(d,l-lactic-co-glycolide) (PLGA) and PLGA-b-poly(ethylene
glycol) (PLGA-b-PEG) microparticles with tunable
surface textures were generated by combining the interfacial instabilities
of emulsion droplet and polymer-blending strategy. Monodisperse emulsion
droplets containing polymers were generated through the microfluidic
flow-focusing technique. The removal of organic solvent from the droplets
triggered the interfacial instabilities (spontaneous increase in interfacial
area), leading to the formation of uniform polymer particles with
textured surfaces. With the introduction of homopolymer PLGA to PLGA-b-PEG, the hydrophobicity of the polymer system was tailored,
and a qualitatively different interfacial behavior of the emulsion
droplets during solvent removal was observed. Uniform polymer particles
with tunable surface roughness were thus generated by changing the
ratio of PLGA-b-PEG in the polymer blends. More interestingly,
surface textures of the particles determined the drug-loading efficiency
and release kinetics of the encapsulated hydrophobic paclitaxel, which
followed a diffusion-directed drug-release pattern. The polymer particles
with different surface textures demonstrated good cell viability and
biocompatibility, indicating the promising role of the particles in
the fields of drug or gene delivery for tumor therapy, vaccines, biodiagnostics,
and bioimaging.
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Monodisperse emulsion dropletstunable surface texturesmicrofluidic flow-focusing techniquediffusion-directed drug-release patternBiodegradable Polymer MicroparticlesPEGuniform polymer particlesTuning Surface TexturesPLGAtunable surface roughnessUniform polymer particlessurface texturespolymer particles
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