Regio- and Stereoselective Cyanotriflation of Alkynes Using Aryl(cyano)iodonium Triflates

2016-02-18T00:00:00Z (GMT) by Xi Wang Armido Studer
A novel, mild, and versatile approach for regioselective <i>syn</i>-addition of both the CN and OTf groups of aryl­(cyano)­iodonium triflates to alkynes is described. The reaction uses Fe-catalysis and can be conducted in gram scale. Products of the vicinal cyanotriflation can be stereospecifically readily further functionalized, rendering the method highly valuable.