Recruitment flowchart.

<p><b>Patients diagnosed with PP at CMUH between 2006 and 2015.</b> Early puberty group (T-ep): Breast development beginning at 8–10 years of age or menarche at 10–12 years of age, as defined here. Idiopathic central precocious puberty group (T-icpp): Breast development beginning before 8 years of age, or menarche before 10 years of age.</p>