Re-examination of genetic and nutritional factors related to trichothecene biosynthesis in Fusarium graminearum

Disruption of two Fusarium genes that negatively regulate trichothecene biosynthesis was reported to cause a drastic increase in trichothecene production. However, careful inspection of these genes revealed that neither was significantly related to trichothecene production. Agmatine medium maintained the expression of trichothecene genes at significant levels, resulting in a 2–3-fold increase in the final yield, as compared to glutamine medium.